In severe cases of anemia due to folate deficiency, your brain receives less oxygen than it would ideally need. The result is that the arteries in the brain swell and cause headaches. But your brain is not the only organ that lacks oxygen, so you can also feel pain in other parts of the body that suffer from iron deficiency, specifically the chest and legs.
5. Pale skin
Hemoglobin is a protein contained in red blood cells and is responsible for transporting oxygen from the lungs to body tissues.
When your body lacks folate, it doesn’t have enough red blood cells (and hemoglobin) to supply your internal organs with the necessary amount of oxygen. This can cause muscle weakness, tiredness and numbness in your hands and feet, as well as the appearance of pale skin.